A New-Generation Method for Quick and Owren PT
نویسندگان
چکیده
Oral anticoagulant therapy (OAT) calls for continuous control by prothrombin time (PT) test, as the therapeutic range in INR units is very narrow. Warfarin (or coumarin) inhibits coagulation factor synthesis in the liver, but at the same time inactive coagulation factors are formed. The aim here was to measure "active coagulation factors" and inhibition in calibrator kits and patient plasmas by a new method for Quick and Owren PT. Four calibration kits and 200 plasma samples obtained from OAT patients were assessed using Quick and Owren PT for INRTot (active coagulation factors + inhibition) and INRAcf (only active coagulation factors). Conspicuous variation in inhibition was noted between the four calibration kits. The newgeneration PT method develops anticoagulation therapy based on active coagulation factors in vivo and improves INR result harmonization for Quick and Owren PT reagents. This new approach improves Quick PT reliability.
منابع مشابه
A sensitivity comparison of the Quick and Owren prothrombin time methods in oral anticoagulant therapy
Prothrombin time (PT) is the leading test for monitoring oral anticoagulation therapy (OAT). According to the World Health Organization recommendation, International Normalized Ratio (INR) results obtained from the same patient samples with the major PT methods (Quick and Owren) should be the same when the therapeutic range is the same. In our study blood samples were obtained from 207 OAT pati...
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